When refilling a prescription dispensed in a child-resistant container, what must a pharmacist always replace?

When refilling a prescription that was originally dispensed in a child-resistant container, the pharmacist is required to replace the plastic closure. The primary purpose of the child-resistant container is to provide safety by making it difficult for children to access the medication. The plastic closure is the component that ensures the container remains child-resistant, as it generally has a specific locking mechanism or design that prevents easy opening by young children.

Replacing the plastic closure ensures that the safety features of the original container are maintained with each refill, providing continuous protection. While the bottle may be replaced if it is damaged or the label updated if there are changes in dosage instructions, the crucial element for child safety is the integrity of the closure itself. Additionally, the inner seal is secondary to the effectiveness of the closure in maintaining child resistance, which is paramount. Thus, replacing the plastic closure is essential for compliance with safety regulations concerning the dispensing of prescription medications.